Desmond Lun Thesis

As determining how the cancer arrests healthy blood production could have significant ramifications for the design and development of treatments for leukaemia, a multi-disciplinary international team undertook two related, experimentally sophisticated, studies to address this question by studying an aggressive AML model in mice that mimics the disease found in humans. Hawkins), in collaboration with myself and my ex-postdoc Tom Weber who is now at WEHI.The first study was undertaken by members of Cristina Lo Celso's wet lab at Imperial College London (Olufolake Akinduro, Heather Ang, Myriam Haltalli, Nicola Ruvio, Delfim Duarte, N. To accurately determine the proliferation dynamics of both healthy blood cell production and cancer growth, as well as careful measurements of cell numbers, we implemented a method to measure the rate of cell division in vivo.

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This study (Cell Stem Cell, 2018), found that leukaemia expanded in a few areas initially, gradually eliminating healthy blood cells, cells that support blood production, and the rare blood vessels normally associated with blood stem cells.

By preserving those rare blood vessels with a pharmaceutical intervention it was established that healthy blood stem cells could be rescued and chemotherapeutic efficacy promoted.

The stem cells that are the top of the hierarchy of healthy blood cell production proved most resistant to this process, but were ultimately eliminated.

En route, we identified an improved phenotypic characterization of true blood stem cells.

That is, in the collection of optical techniques that enable visualization of biological processes in live animals.

In a second study, led by her team, but encompassing a large network of researchers and clinicians spanning Glasgow to Melbourne, amongst other tools, this approach was leveraged to get to the bottom of that question.While the first study, described above, provides a cellular population-level understanding of how leukaemia outcompetes healthy blood cell production, to get a grasp on why stem cells manage to resist ousting from bone marrow required distinct techniques.Cristina Lo Celso's wet lab at Imperial College London are recognised experts in intravital microscopy.Crime-scene samples, in particular, can be a challenge to interpret and analyse.They typically contain source material from an unknown number of individuals and are often degraded by the environment, making inference as to whether someone is in the mix a significant challenge.Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984 | 1983 | 1982 | 1981 | 1980 | 1979 | 1978 | 1977 | 1976 | 1975 | 1974 | 1973 | 1972 | 1971 | 1970 | 1969 | 1968 | 1967 | 1966 | 1965 | 1964 | 1963 | 1962 | 1961 | 1960 | 1959 | 1958 | 1957 | 1956 | 1955 | 1954 | 1953 | 1952 | 1951 | 1950 | 1949 | 1948 | 1947 | 1945 | 1944 | 1943 | 1942 | 1940 | 1939 | 1938 | 1937 | 1936 | 1935 | 1934 | 1933 | 1932 | 1931 | 1930 | 1929The new trade / new growth nexus for late industrialisers : exploring learning-by-doing processes for garment (Cambodia, Bangladesh) and cut-flower (Kenya, Ethiopia) exporters : integrating global value chain and firm-level analyses.Transition in the Japanese Youth Cinema (1956-1960): from the Taiyōzoku Phenomenon to the New Wave. Comparative Analysis, Contextual Parameters and Thematic and Formal Transgressions. The visual representations of Bodhidharma in East Asian art with a special emphasis on the Korean Bodhidharma-paintings and the formation of Bodhidharma's iconography.Institutions and vessels in East Asia: Exploring a new approach for the study of medieval and early modern wares, applied to the origin of early Ming imperial underglaze blue ceramics and their introduction into Korea.A survey of representative land charters of the Ethiopian Empire (1314-1868) and related marginal notes in manuscripts in the British Library, the Royal Library and the university libraries of Cambridge and Manchester.Creating Network Codes for non-multicast transmissions where different users want different streams, however, is remains challenging.In work led by Ying Cu, (Shanghai Jiao Tong University), with Muriel Médard, Edmund Yeh, Douglas J.

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  • Doctoral Dissertations Available from Proquest Dissertations.
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    Brown, Garth Desmond 2002 Preparation of ordered nanocomposites in. Liu, Tien-Lun 1998 A coordinated constraint-based modeling and design.…

  • Natural-Language Video Description with Deep Recurrent.
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    The Dissertation Committee for Subhashini Venugopalan certifies that this is the approved version of the. niques presented in this thesis view the task of video description akin to machine translation. Desmond Elliott and Frank Keller. Comparing. 2014. 15. Ke Zhang, Wei-Lun Chao, Fei Sha, and Kristen Grauman.…

  • PhD Dissertation - The University of Texas at Austin
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    E Dissertation Commi ee for Karthikeyan Shanmugam certi es that this is the approved. 58 Tracey Ho and Desmond Lun. Network coding an introduction.…

  • Nicholas Higham - Wikipedia
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    Thesis · Nearness Problems in Numerical Linear Algebra 1985. Doctoral advisor, George Hall. Website, · nickhigham. Nicholas John Higham FRS born 25 December 1961 in Salford is a British numerical analyst. and MATLAB Guide, co-authored with his brother Desmond Higham.…

  • Cai Lun MY HERO
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    Apr 29, 2016. My hero is Cai Lun. He was from East Han Dynasty in China. He was one of the inventors of China's 4 great inventions in history, and he was.…

  • Alumni List Yale Department of Chemistry
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    Dr. Desmond Sheehan, M. S. 1961, Ph. D. 1964. Dr. Stafford W. Sheehan, M. S. 2013. Dr. Lun K. Tsou, M. S. 2005, Ph. D. 2007. Dr. Shu-I Tu, 1968, Ph. D.…

  • Weeks Lab People - Emory Physics
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    Yonglun Jiang grad student, emulsions, 712-8669, 360A, yonglun.jiang / Steven Rhodes. B. S. in physics, May '11; honors thesis. Ph. D. in.…

  • Staphylococcus aureus - mBio
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    Jan 23, 2018. Jeffrey M. Boyd,f Desmond S. Lun,c. Boyd JM, Lun DS, Torres VJ. 2018. thesis is controlled by flux across the reaction catalyzed by.…

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