Dissertation Process Analytical Technology

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In addition, the candidate will present findings at conferences, in scientific publications, and enable industry-wide adaptation of technological advances.

IMA Active and VIAVI Solutions have the pleasure of inviting you to the symposium “PAT and Qb D in the solid dosage manufacturing: NIR integration from an engineering perspective”. (Founder at Optimal) Martin graduated in engineering with an honours degree from the University of Bath in the late 1970’s, when still we wrote with quill pens and electricity was a new novelty.

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Available from: Next chapter By Vânia Maria Borges Cunha, Marcilene Paiva da Silva, Wanessa Almeida da Costa, Mozaniel Santana de Oliveira, Fernanda Wariss Figueiredo Bezerra, Anselmo Castro de Melo, Rafael Henrique Holanda Pinto, Nelio Teixeira Machado, Marilena Emmi Araujo and Raul Nunes de Carvalho Junior We are Intech Open, the world's leading publisher of Open Access books. Our readership spans scientists, professors, researchers, librarians, and students, as well as business professionals.

The calibration is built upon Partial Least Squares regression of NIR spectra and reference values generated by loss on drying on a halogen dryer.

It is possible to predict the water content in the calibrated range with a precision comparable to the one of the reference method. Process Analytical Technology for CO2 Capture, Carbon Dioxide Chemistry, Capture and Oil Recovery, Iyad Karamé, Janah Shaya and Hassan Srour, Intech Open, DOI: 10.5772/intechopen.76176.The Strategic Analytics group, part of Analytical Development, has an opportunity for a Scientist I/II as a subject matter expert in process analytical technology (PAT).Based on this knowledge, reasonable specifications for routine manufacturing can be selected and process windows or design spaces for single unit operations can be implemented.Project B involves an active coating process of tablet cores in a drum coater, where tablets are layered by a film-coating liquid containing the Active Pharmaceutical Ingredient (API).Higher inlet air temperature has a positive correlation with particle size resulting in increased D50 values, while lower product temperatures yield larger granules.Besides, a NIRS calibration model applying a fibre optic probe and diffuse reflection measuring mode was developed for in-line moisture monitoring during the granulation process.This thesis discusses the potential applications of process analytical techniques (PAT) and associated benefits of exploiting such in-line and at-line measurement tools during process development of solid dosage forms using case studies of two different development projects.The most critical unit operations of the manufacturing process affecting downstream processability and Critical Quality Attributes of the final drug product to a great extent were fluid bed granulation for the first project (Project A) and active coating of tablets for the second project (Project B).In the last section, important regulatory requirements concerning the submission of PAT data and specifics for NIR data are summarised. Process Analytical Technology for CO2 Capture, Carbon Dioxide Chemistry, Capture and Oil Recovery, Iyad Karamé, Janah Shaya and Hassan Srour, Intech Open, DOI: 10.5772/intechopen.76176.

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