Research Paper On Leukemia

Research Paper On Leukemia-83
According to many studies, leukemic cell heterogeneity in APL influences the clinical outcome of disease.The analysis of certain leukemic cell characteristics on the clinical outcome in our study revealed that patients with bcr3 had shorter medians of first remission and survival in comparison to patients with the bcr1 isoform of PML/RARalpha.

According to many studies, leukemic cell heterogeneity in APL influences the clinical outcome of disease.

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Her laboratory investigation showed patient being in disseminated intravascular coagulation.

Complete blood counts and Bone marrow examination showed significant promyelocytes and blasts with flow cytometric analysis consistent with acute promyelocytic leukemia (APL).

The chromosomal aberration in 95% of APL cases is t(15; 17) (q22; q21), which prevents cell differentiation.

Characterization of the underlying molecular lesion is valuable in determining optimal treatment strategy.

BACKGROUND: Acute Promyelocytic Leukemia (APL) is a subclass of acute myeloid leukemia.

The chromosomal aberration in 95% of APL cases is t(15; 17) (q22; q21), which prevents cell differentiation. more BACKGROUND: Acute Promyelocytic Leukemia (APL) is a subclass of acute myeloid leukemia.

CNS involvement was diagnosed based on the appearance of APL blasts in cerebrospinal fluid (CSF).

After treated with all-trans retinoic acid (ATRA), idarubicin, cytarabine and intrathecal methotrexate, she achieved morphological, molecular, and CNS remission.

There are three M3 morphologic variants: the typical hypergranular form and the microgranular and basophilic variants.

Although most leukemic cells in M3 patients express t(15;17), other cytogenetic abnormalities have also been reported.

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